Ana Rath is a medical doctor with a background in general surgery and a Master degree in Philosophy. She oriented her career to medical information and terminologies in 1997 and joined Orphanet (www.orpha.net) in 2005, where she acted as the Manager of the Orphanet Encyclopaedia, then as Scientific Director. Ana is currently the Director of Orphanet and Coordinator of the Orphanet network since 2014. She coordinated RD-ACTION, the Eripean Joint Action for rare diseases (2015-2018) and of the International Rare Diseases research Consortium (IRDiRC)’s scientific secretariat until 2017. She was member of the WHO’s ICD11 Revision Steering Committee. She coordinated the development of the Orphanet Nomenclature of rare diseases (ORPHAcodes) since 2006, and chairs the Orphanet Rare Disease Ontology (ORDO). Since 2017, she coordinates projects on the production, de delivery and the implementation of RD codification in EU member states (RD-CODE, OD4RD) and coordinates the participation of Orphanet in projects preparing the European Health Data Space (X-eHealth, EHDS Pilot 2), as well as the task on Semantics for rare disease data in JARDIN Joint action. She co-chairs the ERDERA Data Service Hub on data and resources ecosystem for RD research in Europe. She acts as a Commissioner in the Lancet Commission for Rare Diseases.